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Effect of chlorine dioxide and metabolites on glutathione dependent system in rat, mouse and chicken blood.
J Environ Pathol Toxicol. 1979 Dec; 3(1-2):451-60.JE

Abstract

Chlorine dioxide (Cl02) has been proposed as an alternative disinfectant to chlorine to avoid formation of organohalides. Cl02 and metabolites, chlorite (Cl0-2) and chlorate (Cl0-3) in drinking water produced decreases in rat and chicken blood GSH. The GSH dependent system was studied in rat and chicken blood after chronic treatment for 6 months with CL02 (0, 1, 10, 100, 1000 MG/L), Cl0-2 or Cl0-3 (10, 100 mg/l) in drinking water. There was a 60% increase in GSH reductase in the Cl02 treatment groups of rats and chickens. A similar increase was shown in rats treated with Cl0-2 but with Cl0-3 no change was observed. GSH peroxidase was without change in rat but chickens drinking 1000 mg/l Cl02 had decreased activity. Catalase was significantly higher than control in rat and chicken in the 1000 mg/l groups. However, catalase activity was decreased in rat treated with Cl0-2 and at the same time that GSH was decreased. These studies support the view that catalase is the first line of defense against the oxidative stress of Cl02 in rat and chicken erythrocytes.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

547025

Citation

Couri, D, and M S. Abdel-Rahman. "Effect of Chlorine Dioxide and Metabolites On Glutathione Dependent System in Rat, Mouse and Chicken Blood." Journal of Environmental Pathology and Toxicology, vol. 3, no. 1-2, 1979, pp. 451-60.
Couri D, Abdel-Rahman MS. Effect of chlorine dioxide and metabolites on glutathione dependent system in rat, mouse and chicken blood. J Environ Pathol Toxicol. 1979;3(1-2):451-60.
Couri, D., & Abdel-Rahman, M. S. (1979). Effect of chlorine dioxide and metabolites on glutathione dependent system in rat, mouse and chicken blood. Journal of Environmental Pathology and Toxicology, 3(1-2), 451-60.
Couri D, Abdel-Rahman MS. Effect of Chlorine Dioxide and Metabolites On Glutathione Dependent System in Rat, Mouse and Chicken Blood. J Environ Pathol Toxicol. 1979;3(1-2):451-60. PubMed PMID: 547025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chlorine dioxide and metabolites on glutathione dependent system in rat, mouse and chicken blood. AU - Couri,D, AU - Abdel-Rahman,M S, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 451 EP - 60 JF - Journal of environmental pathology and toxicology JO - J Environ Pathol Toxicol VL - 3 IS - 1-2 N2 - Chlorine dioxide (Cl02) has been proposed as an alternative disinfectant to chlorine to avoid formation of organohalides. Cl02 and metabolites, chlorite (Cl0-2) and chlorate (Cl0-3) in drinking water produced decreases in rat and chicken blood GSH. The GSH dependent system was studied in rat and chicken blood after chronic treatment for 6 months with CL02 (0, 1, 10, 100, 1000 MG/L), Cl0-2 or Cl0-3 (10, 100 mg/l) in drinking water. There was a 60% increase in GSH reductase in the Cl02 treatment groups of rats and chickens. A similar increase was shown in rats treated with Cl0-2 but with Cl0-3 no change was observed. GSH peroxidase was without change in rat but chickens drinking 1000 mg/l Cl02 had decreased activity. Catalase was significantly higher than control in rat and chicken in the 1000 mg/l groups. However, catalase activity was decreased in rat treated with Cl0-2 and at the same time that GSH was decreased. These studies support the view that catalase is the first line of defense against the oxidative stress of Cl02 in rat and chicken erythrocytes. SN - 0146-4779 UR - https://neuro.unboundmedicine.com/medline/citation/547025/Effect_of_chlorine_dioxide_and_metabolites_on_glutathione_dependent_system_in_rat_mouse_and_chicken_blood_ DB - PRIME DP - Unbound Medicine ER -