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Kinetics of Cl02 and effects of Cl02, Cl02-, and Cl03- in drinking water on blood glutathione and hemolysis in rat and chicken.
J Environ Pathol Toxicol. 1979 Dec; 3(1-2):431-49.JE

Abstract

Since chlorination of drinking water produces organochlorinated substances (some possibly carcinogenic), the use of chlorine dioxide disinfectant would avoid halogenation. There is scarcely any data published on the effects of ClO2 in drinking water on human or animal health. The kinetics of 36ClO2 was studied in rats. Radioactivity was rapidly absorbed from the gastrointestinal tract following the administration of (0.07 microCi) 36ClO2 orally. 36Cl in plasma reached at peak at 1 hr. The half life for the elimination of 36Cl from the rat was 44 hr, corresponding to a rate constant of 0.016 hr-1. After 72 hr radioactivity was highest in plasma, followed by kidney, lung, stomach, duodenum, ileum, liver, spleen, thymus, and bone marrow. 36Cl excretion was greatest at 24 and 48 hrs after the administration of 36 ClO2. Forty-three percent of the total initial dose was excreted at 72 hr in the urine and feces. No 36 Cl was detected in expired air throughout the 72 hr studied. ClO2, ClO2-, and ClO3- (1, 10, 100, 1000 ppm) given daily in drinking water decreased blood glutathione, decreased osmotic fragility, and changed the morphology of erythrocytes in both chicken and rat after two months. Methemoglobin was not detected throughout these studies.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

547024

Citation

Abdel-Rahman, M S., et al. "Kinetics of Cl02 and Effects of Cl02, Cl02-, and Cl03- in Drinking Water On Blood Glutathione and Hemolysis in Rat and Chicken." Journal of Environmental Pathology and Toxicology, vol. 3, no. 1-2, 1979, pp. 431-49.
Abdel-Rahman MS, Couri D, Bull RJ. Kinetics of Cl02 and effects of Cl02, Cl02-, and Cl03- in drinking water on blood glutathione and hemolysis in rat and chicken. J Environ Pathol Toxicol. 1979;3(1-2):431-49.
Abdel-Rahman, M. S., Couri, D., & Bull, R. J. (1979). Kinetics of Cl02 and effects of Cl02, Cl02-, and Cl03- in drinking water on blood glutathione and hemolysis in rat and chicken. Journal of Environmental Pathology and Toxicology, 3(1-2), 431-49.
Abdel-Rahman MS, Couri D, Bull RJ. Kinetics of Cl02 and Effects of Cl02, Cl02-, and Cl03- in Drinking Water On Blood Glutathione and Hemolysis in Rat and Chicken. J Environ Pathol Toxicol. 1979;3(1-2):431-49. PubMed PMID: 547024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of Cl02 and effects of Cl02, Cl02-, and Cl03- in drinking water on blood glutathione and hemolysis in rat and chicken. AU - Abdel-Rahman,M S, AU - Couri,D, AU - Bull,R J, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 431 EP - 49 JF - Journal of environmental pathology and toxicology JO - J Environ Pathol Toxicol VL - 3 IS - 1-2 N2 - Since chlorination of drinking water produces organochlorinated substances (some possibly carcinogenic), the use of chlorine dioxide disinfectant would avoid halogenation. There is scarcely any data published on the effects of ClO2 in drinking water on human or animal health. The kinetics of 36ClO2 was studied in rats. Radioactivity was rapidly absorbed from the gastrointestinal tract following the administration of (0.07 microCi) 36ClO2 orally. 36Cl in plasma reached at peak at 1 hr. The half life for the elimination of 36Cl from the rat was 44 hr, corresponding to a rate constant of 0.016 hr-1. After 72 hr radioactivity was highest in plasma, followed by kidney, lung, stomach, duodenum, ileum, liver, spleen, thymus, and bone marrow. 36Cl excretion was greatest at 24 and 48 hrs after the administration of 36 ClO2. Forty-three percent of the total initial dose was excreted at 72 hr in the urine and feces. No 36 Cl was detected in expired air throughout the 72 hr studied. ClO2, ClO2-, and ClO3- (1, 10, 100, 1000 ppm) given daily in drinking water decreased blood glutathione, decreased osmotic fragility, and changed the morphology of erythrocytes in both chicken and rat after two months. Methemoglobin was not detected throughout these studies. SN - 0146-4779 UR - https://neuro.unboundmedicine.com/medline/citation/547024/Kinetics_of_Cl02_and_effects_of_Cl02_Cl02__and_Cl03__in_drinking_water_on_blood_glutathione_and_hemolysis_in_rat_and_chicken_ DB - PRIME DP - Unbound Medicine ER -