TY - JOUR T1 - The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial. AU - Milajerdi,Alireza, AU - Jazayeri,Shima, AU - Shirzadi,Elham, AU - Hashemzadeh,Najmeh, AU - Azizgol,Atieh, AU - Djazayery,Abolghassem, AU - Esmaillzadeh,Ahmad, AU - Akhondzadeh,Shahin, Y1 - 2018/09/26/ PY - 2018/07/16/received PY - 2018/09/24/revised PY - 2018/09/24/accepted PY - 2018/11/28/entrez PY - 2018/11/28/pubmed PY - 2019/3/9/medline KW - Comorbid depression-anxiety KW - Crocus satious L. KW - Life satisfaction KW - Saffron KW - Sleep quality KW - Type 2 diabetes mellitus SP - 196 EP - 202 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 41 N2 - OBJECTIVE: Depression and anxiety are major health problems throughout the world. Metabolic changes in type 2 diabetes mellitus induces and aggravates mental disorders, such as depression and anxiety. Saffron as a therapeutic herb may attenuate Comorbid Depression- Anxiety (CDA). So, this trial is designed to investigate the effect of saffron alcoholic extract on symptoms of CDA in type 2 diabetic patients. METHODS: Fifty-four outpatients suffered from mild to moderate CDA diagnosed by using Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV), were assessed by Hamilton Depression and anxiety measurements, the Pittsburgh Sleep Quality Index (PSQI), and the Satisfaction with Life Scale (SWLS). The participants of this double-blind, placebo-controlled, single center and randomized trial were randomly assigned to intake 30 mg/day saffron or placebo capsules for 8 weeks. RESULTS: After the intervention, mild to moderate CDA, anxiety and sleep disturbance, but not depression alone, were relieved significantly in the saffron group (P < 0.05), whereas, the changes were not significant in the placebo group. Anthropometric measures and blood pressure parameters of the patients in either groups did not change significantly (P > 0.05) during the intervention. Moreover, dietary intake and physical activity did not differ during the study in the two groups. Changes in the life satisfaction were not significant. CONCLUSION: The results indicate the beneficial effect of saffron on the mild to moderate CDA in type 2 diabetic patients. SN - 1873-6963 UR - https://neuro.unboundmedicine.com/medline/citation/30477839/The_effects_of_alcoholic_extract_of_saffron__Crocus_satious_L___on_mild_to_moderate_comorbid_depression_anxiety_sleep_quality_and_life_satisfaction_in_type_2_diabetes_mellitus:_A_double_blind_randomized_and_placebo_controlled_clinical_trial_ DB - PRIME DP - Unbound Medicine ER -