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The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial.
Complement Ther Med. 2018 Dec; 41:196-202.CT

Abstract

OBJECTIVE

Depression and anxiety are major health problems throughout the world. Metabolic changes in type 2 diabetes mellitus induces and aggravates mental disorders, such as depression and anxiety. Saffron as a therapeutic herb may attenuate Comorbid Depression- Anxiety (CDA). So, this trial is designed to investigate the effect of saffron alcoholic extract on symptoms of CDA in type 2 diabetic patients.

METHODS

Fifty-four outpatients suffered from mild to moderate CDA diagnosed by using Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV), were assessed by Hamilton Depression and anxiety measurements, the Pittsburgh Sleep Quality Index (PSQI), and the Satisfaction with Life Scale (SWLS). The participants of this double-blind, placebo-controlled, single center and randomized trial were randomly assigned to intake 30 mg/day saffron or placebo capsules for 8 weeks.

RESULTS

After the intervention, mild to moderate CDA, anxiety and sleep disturbance, but not depression alone, were relieved significantly in the saffron group (P < 0.05), whereas, the changes were not significant in the placebo group. Anthropometric measures and blood pressure parameters of the patients in either groups did not change significantly (P > 0.05) during the intervention. Moreover, dietary intake and physical activity did not differ during the study in the two groups. Changes in the life satisfaction were not significant.

CONCLUSION

The results indicate the beneficial effect of saffron on the mild to moderate CDA in type 2 diabetic patients.

Authors+Show Affiliations

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.Department of Nutrition, School of Health, Iran University of Medical Sciences, Tehran, Iran.Isfahan Diabetes Society, Natanz, Isfahan, Iran.Isfahan Diabetes Society, Natanz, Isfahan, Iran.Isfahan Diabetes Society, Natanz, Isfahan, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: a-esmaillzadeh@tums.ac.ir.Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: s.akhond@neda.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30477839

Citation

Milajerdi, Alireza, et al. "The Effects of Alcoholic Extract of Saffron (Crocus Satious L.) On Mild to Moderate Comorbid Depression-anxiety, Sleep Quality, and Life Satisfaction in Type 2 Diabetes Mellitus: a Double-blind, Randomized and Placebo-controlled Clinical Trial." Complementary Therapies in Medicine, vol. 41, 2018, pp. 196-202.
Milajerdi A, Jazayeri S, Shirzadi E, et al. The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial. Complement Ther Med. 2018;41:196-202.
Milajerdi, A., Jazayeri, S., Shirzadi, E., Hashemzadeh, N., Azizgol, A., Djazayery, A., Esmaillzadeh, A., & Akhondzadeh, S. (2018). The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial. Complementary Therapies in Medicine, 41, 196-202. https://doi.org/10.1016/j.ctim.2018.09.023
Milajerdi A, et al. The Effects of Alcoholic Extract of Saffron (Crocus Satious L.) On Mild to Moderate Comorbid Depression-anxiety, Sleep Quality, and Life Satisfaction in Type 2 Diabetes Mellitus: a Double-blind, Randomized and Placebo-controlled Clinical Trial. Complement Ther Med. 2018;41:196-202. PubMed PMID: 30477839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial. AU - Milajerdi,Alireza, AU - Jazayeri,Shima, AU - Shirzadi,Elham, AU - Hashemzadeh,Najmeh, AU - Azizgol,Atieh, AU - Djazayery,Abolghassem, AU - Esmaillzadeh,Ahmad, AU - Akhondzadeh,Shahin, Y1 - 2018/09/26/ PY - 2018/07/16/received PY - 2018/09/24/revised PY - 2018/09/24/accepted PY - 2018/11/28/entrez PY - 2018/11/28/pubmed PY - 2019/3/9/medline KW - Comorbid depression-anxiety KW - Crocus satious L. KW - Life satisfaction KW - Saffron KW - Sleep quality KW - Type 2 diabetes mellitus SP - 196 EP - 202 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 41 N2 - OBJECTIVE: Depression and anxiety are major health problems throughout the world. Metabolic changes in type 2 diabetes mellitus induces and aggravates mental disorders, such as depression and anxiety. Saffron as a therapeutic herb may attenuate Comorbid Depression- Anxiety (CDA). So, this trial is designed to investigate the effect of saffron alcoholic extract on symptoms of CDA in type 2 diabetic patients. METHODS: Fifty-four outpatients suffered from mild to moderate CDA diagnosed by using Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV), were assessed by Hamilton Depression and anxiety measurements, the Pittsburgh Sleep Quality Index (PSQI), and the Satisfaction with Life Scale (SWLS). The participants of this double-blind, placebo-controlled, single center and randomized trial were randomly assigned to intake 30 mg/day saffron or placebo capsules for 8 weeks. RESULTS: After the intervention, mild to moderate CDA, anxiety and sleep disturbance, but not depression alone, were relieved significantly in the saffron group (P < 0.05), whereas, the changes were not significant in the placebo group. Anthropometric measures and blood pressure parameters of the patients in either groups did not change significantly (P > 0.05) during the intervention. Moreover, dietary intake and physical activity did not differ during the study in the two groups. Changes in the life satisfaction were not significant. CONCLUSION: The results indicate the beneficial effect of saffron on the mild to moderate CDA in type 2 diabetic patients. SN - 1873-6963 UR - https://neuro.unboundmedicine.com/medline/citation/30477839/The_effects_of_alcoholic_extract_of_saffron__Crocus_satious_L___on_mild_to_moderate_comorbid_depression_anxiety_sleep_quality_and_life_satisfaction_in_type_2_diabetes_mellitus:_A_double_blind_randomized_and_placebo_controlled_clinical_trial_ DB - PRIME DP - Unbound Medicine ER -