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The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina.
Clin Nutr ESPEN. 2018 08; 26:47-52.CN

Abstract

BACKGROUND

Despite advances in the treatment of cardiovascular diseases in recent decades, patients experience high levels of depression, anxiety, stress, and insomnia. Since the calming effect of Melissa officinalis (MO) has been known, this study aimed to determine the effects of MO supplementation on depression, anxiety, stress, and sleep disturbances in patients with chronic stable angina (CSA).

METHODS

In this double-blind placebo-controlled clinical trial, 80 patients with CSA were divided randomly into two groups (taking 3 g MO supplement or placebo daily for 8 weeks). The shortened 21-item version of the depression, anxiety and stress scale (DASS-21) test and Pittsburgh sleep quality index were done before and after the intervention.

RESULTS

At the end of the study, the intervention group receiving MO capsules had a significant reduction in scores of depression, anxiety, stress, and total sleep disturbance, compared with the placebo group (P < 0.05).

CONCLUSIONS

The results showed that 8-week supplementation with 3 g MO can decrease depression, anxiety, stress, and sleep disorder in patients with CSA.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Haybar H
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Javid AZ
Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Haghighizadeh MH
Department of Biostatics, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Valizadeh E
Department of Biology, Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohaghegh SM
Department of Nutrition Sciences, School of Para-medicine, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mohammadzadeh A
Department of Nutrition Sciences, School of Para-medicine, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: mohammadzadeh.a@ajums.ac.ir.

MeSH

AdultAgedAngina, StableAnti-Anxiety AgentsAntidepressive AgentsAnxietyChronic DiseaseDepressionDouble-Blind MethodFemaleHumansHypnotics and SedativesIranMaleMelissaMiddle AgedPlant ExtractsSleepSleep Wake DisordersStress, PsychologicalTime FactorsTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29908682

Clinical Trial Links

Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)

Citation

Haybar, Habib, et al. "The Effects of Melissa Officinalis Supplementation On Depression, Anxiety, Stress, and Sleep Disorder in Patients With Chronic Stable Angina." Clinical Nutrition ESPEN, vol. 26, 2018, pp. 47-52.
Haybar H, Javid AZ, Haghighizadeh MH, et al. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN. 2018;26:47-52.
Haybar, H., Javid, A. Z., Haghighizadeh, M. H., Valizadeh, E., Mohaghegh, S. M., & Mohammadzadeh, A. (2018). The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clinical Nutrition ESPEN, 26, 47-52. https://doi.org/10.1016/j.clnesp.2018.04.015
Haybar H, et al. The Effects of Melissa Officinalis Supplementation On Depression, Anxiety, Stress, and Sleep Disorder in Patients With Chronic Stable Angina. Clin Nutr ESPEN. 2018;26:47-52. PubMed PMID: 29908682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. AU - Haybar,Habib, AU - Javid,Ahmad Zare, AU - Haghighizadeh,Mohammad Hosein, AU - Valizadeh,Einollah, AU - Mohaghegh,Seyede Marjan, AU - Mohammadzadeh,Assieh, Y1 - 2018/05/19/ PY - 2017/12/14/received PY - 2018/04/05/revised PY - 2018/04/25/accepted PY - 2018/6/18/entrez PY - 2018/6/18/pubmed PY - 2019/9/11/medline KW - Anxiety KW - Chronic stable angina KW - Depression KW - Melissa officinalis KW - Stress SP - 47 EP - 52 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 26 N2 - BACKGROUND: Despite advances in the treatment of cardiovascular diseases in recent decades, patients experience high levels of depression, anxiety, stress, and insomnia. Since the calming effect of Melissa officinalis (MO) has been known, this study aimed to determine the effects of MO supplementation on depression, anxiety, stress, and sleep disturbances in patients with chronic stable angina (CSA). METHODS: In this double-blind placebo-controlled clinical trial, 80 patients with CSA were divided randomly into two groups (taking 3 g MO supplement or placebo daily for 8 weeks). The shortened 21-item version of the depression, anxiety and stress scale (DASS-21) test and Pittsburgh sleep quality index were done before and after the intervention. RESULTS: At the end of the study, the intervention group receiving MO capsules had a significant reduction in scores of depression, anxiety, stress, and total sleep disturbance, compared with the placebo group (P < 0.05). CONCLUSIONS: The results showed that 8-week supplementation with 3 g MO can decrease depression, anxiety, stress, and sleep disorder in patients with CSA. SN - 2405-4577 UR - https://neuro.unboundmedicine.com/medline/citation/29908682/The_effects_of_Melissa_officinalis_supplementation_on_depression_anxiety_stress_and_sleep_disorder_in_patients_with_chronic_stable_angina_ DB - PRIME DP - Unbound Medicine ER -