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Frontal cortex functioning in the infant broader autism phenotype.
Infant Behav Dev. 2010 Dec; 33(4):482-91.IB

Abstract

Atypical attention has been proposed as a marker of the broader autism phenotype. In the present study we investigated this and the related process of inhibitory control at the youngest possible age through the study of infant siblings of children with an autism spectrum disorder (Sibs-ASD). Both attention and inhibition have been related to the frontal cortex of the brain. Nine- to ten-month-old Sibs-ASD and low-risk control infants completed the Freeze-Frame task, in which infants are encouraged to inhibit looks to peripherally presented distractors whilst looking at a central animation. The attractiveness of the central stimulus is varied in order to investigate the selectivity of infants' responses. In line with previous studies, it was found that a subset of Sibs-ASD infants had difficulty disengaging attention from a central stimulus in order to orient to a peripheral stimulus. The Sibs-ASD group also showed less Selective Inhibition than controls. However, Sibs-ASD infants did demonstrate Selective Inhibitory Learning. These results provide preliminary evidence for atypical frontal cortex functioning in the infant broader autism phenotype.

Authors+Show Affiliations

Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, London, United Kingdom. karla.holmboe@kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20609478

Citation

Holmboe, Karla, et al. "Frontal Cortex Functioning in the Infant Broader Autism Phenotype." Infant Behavior & Development, vol. 33, no. 4, 2010, pp. 482-91.
Holmboe K, Elsabbagh M, Volein A, et al. Frontal cortex functioning in the infant broader autism phenotype. Infant Behav Dev. 2010;33(4):482-91.
Holmboe, K., Elsabbagh, M., Volein, A., Tucker, L. A., Baron-Cohen, S., Bolton, P., Charman, T., & Johnson, M. H. (2010). Frontal cortex functioning in the infant broader autism phenotype. Infant Behavior & Development, 33(4), 482-91. https://doi.org/10.1016/j.infbeh.2010.05.004
Holmboe K, et al. Frontal Cortex Functioning in the Infant Broader Autism Phenotype. Infant Behav Dev. 2010;33(4):482-91. PubMed PMID: 20609478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frontal cortex functioning in the infant broader autism phenotype. AU - Holmboe,Karla, AU - Elsabbagh,Mayada, AU - Volein,Agnes, AU - Tucker,Leslie A, AU - Baron-Cohen,Simon, AU - Bolton,Patrick, AU - Charman,Tony, AU - Johnson,Mark H, Y1 - 2010/07/06/ PY - 2009/09/30/received PY - 2010/02/14/revised PY - 2010/05/20/accepted PY - 2010/7/9/entrez PY - 2010/7/9/pubmed PY - 2011/3/24/medline SP - 482 EP - 91 JF - Infant behavior & development JO - Infant Behav Dev VL - 33 IS - 4 N2 - Atypical attention has been proposed as a marker of the broader autism phenotype. In the present study we investigated this and the related process of inhibitory control at the youngest possible age through the study of infant siblings of children with an autism spectrum disorder (Sibs-ASD). Both attention and inhibition have been related to the frontal cortex of the brain. Nine- to ten-month-old Sibs-ASD and low-risk control infants completed the Freeze-Frame task, in which infants are encouraged to inhibit looks to peripherally presented distractors whilst looking at a central animation. The attractiveness of the central stimulus is varied in order to investigate the selectivity of infants' responses. In line with previous studies, it was found that a subset of Sibs-ASD infants had difficulty disengaging attention from a central stimulus in order to orient to a peripheral stimulus. The Sibs-ASD group also showed less Selective Inhibition than controls. However, Sibs-ASD infants did demonstrate Selective Inhibitory Learning. These results provide preliminary evidence for atypical frontal cortex functioning in the infant broader autism phenotype. SN - 1934-8800 UR - https://neuro.unboundmedicine.com/medline/citation/20609478/Frontal_cortex_functioning_in_the_infant_broader_autism_phenotype_ L2 - https://www.diseaseinfosearch.org/result/673 DB - PRIME DP - Unbound Medicine ER -