Tags

Type your tag names separated by a space and hit enter

Raloxifene improves verbal memory in late postmenopausal women: a randomized, double-blind, placebo-controlled trial.
Menopause. 2010 Mar; 17(2):309-14.M

Abstract

OBJECTIVE

The aim of this study was to examine the effects of raloxifene compared with those of placebo on verbal memory, mental processing speed, depression, anxiety, and quality of life.

METHODS

A randomized, double-blind, placebo-controlled trial of 213 healthy women 70 years or older was conducted between July 2003 and January 2008 at the University Medical Centre Utrecht, the Netherlands. Participants were randomly assigned to receive raloxifene (60 mg) or placebo daily for 12 months. Measurements were taken at baseline and after 3, 6, and 12 months. The change in scores from baseline was calculated. The main outcome measures were direct and delayed verbal memory (Groningen 15 Words test), mental processing speed (Trails B test), mood/depression (Geriatric Depression Scale), anxiety (State-Trait Anxiety Inventory 1 and 2), and quality of life (Women's Health Questionnaire and EuroQol-5 dimensional questionnaire).

RESULTS

Direct verbal memory improved significantly with raloxifene compared with placebo: the women receiving raloxifene repeated more words in the words A + B test than did the women receiving placebo (P = 0.025). At 12 months, the change from baseline was 16 words in the raloxifene group and 10 words in the placebo group. In the words A test, direct repetition was also significantly better among women receiving raloxifene than among women receiving placebo (P = 0.023), with the change from baseline in the number of words repeated being nine words in the raloxifene group and six words in the placebo group at 12 months.

CONCLUSIONS

In postmenopausal women, raloxifene gave significantly improved verbal memory when compared with placebo.

Authors+Show Affiliations

Department of Geriatric Medicine, University Medical Centre Utrecht, GA Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19918203

Citation

Jacobsen, Didy E., et al. "Raloxifene Improves Verbal Memory in Late Postmenopausal Women: a Randomized, Double-blind, Placebo-controlled Trial." Menopause (New York, N.Y.), vol. 17, no. 2, 2010, pp. 309-14.
Jacobsen DE, Samson MM, Emmelot-Vonk MH, et al. Raloxifene improves verbal memory in late postmenopausal women: a randomized, double-blind, placebo-controlled trial. Menopause. 2010;17(2):309-14.
Jacobsen, D. E., Samson, M. M., Emmelot-Vonk, M. H., & Verhaar, H. J. (2010). Raloxifene improves verbal memory in late postmenopausal women: a randomized, double-blind, placebo-controlled trial. Menopause (New York, N.Y.), 17(2), 309-14. https://doi.org/10.1097/gme.0b013e3181bd54df
Jacobsen DE, et al. Raloxifene Improves Verbal Memory in Late Postmenopausal Women: a Randomized, Double-blind, Placebo-controlled Trial. Menopause. 2010;17(2):309-14. PubMed PMID: 19918203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Raloxifene improves verbal memory in late postmenopausal women: a randomized, double-blind, placebo-controlled trial. AU - Jacobsen,Didy E, AU - Samson,Monique M, AU - Emmelot-Vonk,Marielle H, AU - Verhaar,Harald J J, PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/4/17/medline SP - 309 EP - 14 JF - Menopause (New York, N.Y.) JO - Menopause VL - 17 IS - 2 N2 - OBJECTIVE: The aim of this study was to examine the effects of raloxifene compared with those of placebo on verbal memory, mental processing speed, depression, anxiety, and quality of life. METHODS: A randomized, double-blind, placebo-controlled trial of 213 healthy women 70 years or older was conducted between July 2003 and January 2008 at the University Medical Centre Utrecht, the Netherlands. Participants were randomly assigned to receive raloxifene (60 mg) or placebo daily for 12 months. Measurements were taken at baseline and after 3, 6, and 12 months. The change in scores from baseline was calculated. The main outcome measures were direct and delayed verbal memory (Groningen 15 Words test), mental processing speed (Trails B test), mood/depression (Geriatric Depression Scale), anxiety (State-Trait Anxiety Inventory 1 and 2), and quality of life (Women's Health Questionnaire and EuroQol-5 dimensional questionnaire). RESULTS: Direct verbal memory improved significantly with raloxifene compared with placebo: the women receiving raloxifene repeated more words in the words A + B test than did the women receiving placebo (P = 0.025). At 12 months, the change from baseline was 16 words in the raloxifene group and 10 words in the placebo group. In the words A test, direct repetition was also significantly better among women receiving raloxifene than among women receiving placebo (P = 0.023), with the change from baseline in the number of words repeated being nine words in the raloxifene group and six words in the placebo group at 12 months. CONCLUSIONS: In postmenopausal women, raloxifene gave significantly improved verbal memory when compared with placebo. SN - 1530-0374 UR - https://neuro.unboundmedicine.com/medline/citation/19918203/Raloxifene_improves_verbal_memory_in_late_postmenopausal_women:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://doi.org/10.1097/gme.0b013e3181bd54df DB - PRIME DP - Unbound Medicine ER -