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[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

Abstract

The purpose of this article was to study the immunotropic effects of the new neurotrophic heptapeptide selank. The experiments in vitro revealed that the drug in concentration 10-7 M completely suppressed gene expression by peripheral blood IL-6 of patients with depression but not of the healthy controls. At the same time, the significant increase (p<0,05) of IL-6 concentration was observed in the cell culture of peripheral blood of patients in the presence of selank. The changes of the Th1/Th2 cytokine balance in vivo were found in the serum of patients with generalized anxiety disorder and neurasthenia who received Selank during 14 days. The dynamics of these changes had the significant inverse correlation dependence. The cytokine regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders. Additionally, the adaptogenic properties of selank may be beneficial to its use in elderly people and people exposed to environmental stressors for the prevention of infectious diseases.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

18577961

Citation

Uchakina, O N., et al. "[Immunomodulatory Effects of Selank in Patients With Anxiety-asthenic Disorders]." Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, vol. 108, no. 5, 2008, pp. 71-5.
Uchakina ON, Uchakin PN, Miasoedov NF, et al. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5.
Uchakina, O. N., Uchakin, P. N., Miasoedov, N. F., Andreeva, L. A., Shcherbenko, V. E., Mezentseva, M. V., Gabaeva, M. V., Sokolov, O. I. u., Zozulia, A. A., & Ershov, F. I. (2008). [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, 108(5), 71-5.
Uchakina ON, et al. [Immunomodulatory Effects of Selank in Patients With Anxiety-asthenic Disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. PubMed PMID: 18577961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. AU - Uchakina,O N, AU - Uchakin,P N, AU - Miasoedov,N F, AU - Andreeva,L A, AU - Shcherbenko,V E, AU - Mezentseva,M V, AU - Gabaeva,M V, AU - Sokolov,O Iu, AU - Zozulia,A A, AU - Ershov,F I, PY - 2008/6/26/pubmed PY - 2008/10/24/medline PY - 2008/6/26/entrez SP - 71 EP - 5 JF - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova JO - Zh Nevrol Psikhiatr Im S S Korsakova VL - 108 IS - 5 N2 - The purpose of this article was to study the immunotropic effects of the new neurotrophic heptapeptide selank. The experiments in vitro revealed that the drug in concentration 10-7 M completely suppressed gene expression by peripheral blood IL-6 of patients with depression but not of the healthy controls. At the same time, the significant increase (p<0,05) of IL-6 concentration was observed in the cell culture of peripheral blood of patients in the presence of selank. The changes of the Th1/Th2 cytokine balance in vivo were found in the serum of patients with generalized anxiety disorder and neurasthenia who received Selank during 14 days. The dynamics of these changes had the significant inverse correlation dependence. The cytokine regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders. Additionally, the adaptogenic properties of selank may be beneficial to its use in elderly people and people exposed to environmental stressors for the prevention of infectious diseases. SN - 1997-7298 UR - https://neuro.unboundmedicine.com/medline/citation/18577961/[Immunomodulatory_effects_of_selank_in_patients_with_anxiety_asthenic_disorders]_ L2 - https://www.diseaseinfosearch.org/result/7698 DB - PRIME DP - Unbound Medicine ER -